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Exeter boss Rob Baxter says Sam Simmonds will deal with any pressure that might be on him after his England training squad call-up.
Bath pair Joe Cokanasiga and Ben Spencer are both out with knee and hamstring injuries respectively.
Billy and Mako Vunipola plus George Ford are left out of a 45-man squad as eight uncapped players including Louis Lynagh are called up.
Brendan Mullin, 57, faces nine counts of theft and five of false accounting.
St Helens captain James Roby has retired from international duty with immediate effect after a 15-year Test career.
Wakefield Trinity appoint interim boss Willie Poching as head coach, after five wins in seven games at the end of the Super League season.
Salford Red Devils part company with head coach Richard Marshall by mutual consent, after one season in charge of the Super League club.
Team news as Wigan Warriors host Leeds Rhinos in Thursday's Super League elimination play-off at the DW Stadium (19:45 BST).
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