Influential centre Sione Tuipulotu is ruled out of the Six Nations because of the pectoral injury he picked up in training.

Saracens' Phil Morrow will join England as head of performance at the end of the season, after an initial attempt to recruit him was blocked by Premiership clubs.

Sean Lynn is set to leave Gloucester-Hartpury to become Wales women's new head coach.

Fit-again Dan Sheehan and James Lowe are set to return to action for Leinster this week before linking up with Ireland's Six Nations squad.

Northampton Saints will host Clermont Auvergne, Glasgow Warriors will welcome Leicester Tigers and Ulster will travel to top seeds Bordeaux-Begles in the Investec Champions Cup last 16.

England hooker Jamie George goes off injured as three-time winners Saracens fall to a shock 32-24 home defeat by Castres in the Investec Champions Cup.

Sale Sharks book their place in the last 16 of the Investec Champions Cup with a comfortable bonus-point win over Toulon at Salford Community Stadium.

Ulster qualify for the last 16 of the Investec Champions Cup on points difference after Bordeaux claimed a 66-12 victory against Sharks on Sunday.

Holders Toulouse scored 12 tries to hammer Leicester and deny the visitors a home draw in the Investec Champions Cup last 16.

Edinburgh run in five tries to ease past Georgian side Black Lion and secure a home tie in the last 16 of the European Challenge Cup

A much-changed Gloucester suffer a heavy 55-17 defeat in the European Challenge Cup to Bayonne in south-west France.